The DUTCH Cycle MappingTM PLUS not only maps estrogen and progesterone through the monthly menstrual cycle but also adds the comprehensiveness of all the hormone metabolites along with the cortisol awakening response (CAR). Hormonal balance is key. Fluctuating levels of estradiol and progesterone play a major role in a woman’s overall health. This panel is designed for cycling women who struggle with ongoing symptoms such as monthly migraines, fertility issues, or PCOS. The addition of the cortisol awakening response (CAR), a transient, immediate rise in cortisol upon awakening (distinct from the diurnal rhythm), provides a fuller assessment of hor- mone fluctuations, baseline stress response, and reflects a patient’s ability to cope with anticipated challenges. CAR also shows a patient’s perception of control around chronic stress, providing insight into HPA resiliency.